Medications are used as first-line treatment and are associated with a modest improvement in symptoms as measured by the IPSS. For these reasons, a treatment option that has the potential to reduce personal and economic burdens is desirable.Ĭurrent treatment options include medications and interventional procedures, each with associated risks and benefits. Further, these associated expenditures are likely to increase due to the ageing population 3. When considering complications, follow-up visits, treatments, and other tests, the estimated cost for the year following initiation of treatment is €858 when averaged across six European countries 2. In addition to the personal burdens of this illness, LUTS/BPH imposes an economic burden on the healthcare system.
It is thought that by the eighth decade of life nearly all men will develop histological evidence of BPH, which often leads to bothersome symptoms such as urgency, frequency, and nocturia 1. LUTS are some of the most common medical complaints experienced by men as they age. Male Sexual Health Questionnaire for Ejaculatory Dysfunction.Morbidity is low and sexual function is preserved. The PUL procedure is associated with rapid symptom relief, increased urinary flow rate and QoL improvement that remain stable over 24 months. There were no reported instances of de novo sustained erectile or ejaculatory dysfunction. Four patients (8%) required intervention with transurethral resection of the prostate and one patient required additional PUL implants within the 24-month period. Adverse events were typically mild to moderate and patients returned rapidly to normal activity. Symptom response after the sham procedure indicated initial improvement at 1 month with significant decay by 3 months. Each IPSS parameter on average improved significantly from baseline ( P < 0.005) and remained stable throughout follow-up. ResultsĪt 24 months after crossover to PUL, the International Prostate Symptom Score (IPSS), QoL, BPH Impact Index, and maximum urinary flow rate improved 36%, 40%, 54%, and 77% from baseline, respectively. Patients were followed for 3 months after the sham procedure and then for 24 months after crossover to PUL, with assessments of urinary symptom relief, quality of life (QoL), urinary flow rate, sexual function, and adverse events. The crossover procedure involved placement of permanent implants (UroLift ® system) into the prostatic lateral lobes. (Luminal Improvement Following prostatic Tissue approximation for the treatment of LUTS secondary to BPH) study at 19 centres and elected to enrol in this crossover study. In all, 53 patients underwent a sham procedure as part of the blinded, randomised L.I.F.T. To evaluate the 24-month effectiveness of the prostatic urethral lift (PUL) procedure in men with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) assessed through a crossover study.
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